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occurs in an individual who is heterozygous for both loci (A1B2/A2B1, where the forward slash separates the maternal and paternal haplotypes in an individual) With no recombination, A1B2 or A2B1 are inherited as units by an offspring A recombination event would lead to gametes of the types A1B1 and A2B2 Note that the A1B1 type has been seen previously, but the A2B2 type is new With suf cient time, recombination will break down the initial association between A1 and B2 to the point that in the population these two loci will appear to be independent despite their close physical proximity The time required to break down these associations is a function of how close the two markers are It is possible that the markers are so close that one expects there to be a continued association.

This frees employees from mundane tasks to focus instead on the problems or exceptions that arise Step Two will produce further inventory and working capital charge reductions, while redeploying employees to more strategic tasks 3 Step Three Collaboration Partners begin to work more collaboratively They also begin to dynamically shuff le products between facilities and orders, which can allow companies to more easily fulfill orders and further reduce inventory In addition, Step Three enables companies to automatically replenish supplies and materials by tracking consumption from the portal Web site or directly in their respective systems, which is constantly updated Later in this step, businesses shift to their vendors the responsibility for ordering and shipping necessary supplies This leads to massive reductions in inventory as well as working capital.

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The domains of colors associated with each place allow designers to color their tokens and the domains associated with transitions allow them to choose the sets of colors for each ring So to distinguish several instances of the same state, we do not need to replicate places and transitions as for Petri nets, as it is suf cient to color them The pre-conditions (resp the post-conditions) are now speci ed by the color functions attached to the arcs For a transition color c1 and a color place c2 , such a function associates the number of tokens having color c2 which are consumed (resp produced) in each place when the transition is red for the color instance c1 731 Notation To de ne colored nets, let us rst give some basic de nitions DEFINITION 71.

Step Three also improves the production cycle for suppliers, essentially cutting out many emergency production runs and leading to cost savings for all members of the adaptive business network Functions eliminated in Step Three include individual purchase orders and invoicing 4 Step Four Adaptability Partner companies begin to share information about customer demand, such as orders and sales figures, so they can respond to subtle changes as soon as they occur Pervasive technology allows the companies to plan, execute, sense, and respond to business f luctuations with greater ease and at lower cost than before This technology will enable partners to act in concert with existing systems, greatly reducing the time needed for many processes and eliminating others altogether Moreover, a new web of partnerships enables the businesses to better dictate demand and pool their resources for new market and product opportunities.

So long as there remains an association, these markers are considered to be in disequilibrium This is the basis for ne mapping and association studies Although this principle has been illustrated with two arbitrary genetic markers, there is no reason not to consider the situation in which one of these markers is a disease susceptibility locus For example, let the B locus be a disease susceptibility locus In this case we may not know the identity of the B locus (indeed, this is what we are trying to nd), but the genetic disequilibrium between A and B will lead to an association between marker A and the disease When such is found, one can then look in the region of marker A to see the array of genes that are present to nd the functional gene and causative allele At rst glance, the strategy is straightforward.

Most importantly, Step Four lays the foundation for companies to.

The paucity of demonstrated successes in moving from linkage to association to gene identi cation, however, indicates the complexity of the process (Altshuler et al, 2000) As the Human Genome Project and related data mature, it is anticipated that the pace of gene discovery in the context of common diseases will increase The most common paradigm for gene identi cation continues to be one involving moving from linkage to association and then gene identi cation It has been suggested that disequilibrium and disease association could be exploited directly (Kruglyak, 1999) Although this has some obvious appeals related to much simpler sampling designs (eg, association studies do not require more complex pedigree-based sampling), there remain considerable challenges because of the shear numbers of markers that must be typed to achieve adequate genome coverage (Kruglyak, 1999).

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