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marginal distributions on the subspaces {A, B} and {B, C}, we may choose, for instance, two functions AB and BC in such a way that a dom(A) : b dom(B) : c dom(C) : AB (A = a, B = b) = P(A = a, B = b) and P(C = c | B = b), if P(B = b) = 0, BC (B = b, C = c) = 0, otherwise. Note that using factor potentials instead of marginal probability distributions (which would be directly analogous to the relational case) is necessary, since 1 we have to take care of the factor P (B=b) , which has to be incorporated into at least one factor potential of the decomposition. The definitions of the properties of decompositions (trivial, redundant, finer, minimal, etc. cf. Definition 3.2.5 on page 65) carry over directly from the relational case if we replace the set RM of relations by the set M of factor potentials. However, an important difference to the relational case is that for strictly positive probability distributions the minimal decomposition is unique w.r.t. the sets of attributes the factor potentials are defined on (cf. the notion of a minimal independence map in, for example, [Pearl 1988, Castillo et al. 1997]). The exact definition of the factor potentials may still differ, though, as can already be seen from the decomposition formula of the 1 geometrical objects example: the factor P (B=b) may be included in one factor potential or may be distributed to both, for example as 1 .

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Originally published in the Chicago Tribune, January 15, 1996.

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By taking this approach, it is clear how patterns play a vital role in developing scienti c patterns of discovery But understanding recognized patterns is just the beginning of the process of thinking in terms of using patterns to create innovation PATTERNS OF DISCOVERY There are creators who astonish us by the sheer volume of their proli c contributions Thomas Edison is such a man He amassed 1093 patents an unrivaled achievement He began his career in telegraphy and continued to produce communication inventions in a seemingly endless parade of contributions to telephone, radio, phonograph, photography, and motion pictures But he was a genius who could not be contained He went on to develop the electric light, dynamo, motor, electric distribution system, and more His efforts were not only prodigious they were catholic in their methodology.

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For higher grades of VAIN, surgical excision is recommended both as the primary treatment and to con rm the absence of an invasive vaginal cancer. Surgical excision of a focal lesion at the vaginal cuff is usually done in the operating room under regional or general anesthesia. Once adequate anesthesia is achieved, the patient is placed in lithotomy position. After gentle prep of the vagina is performed, either colposcopy is performed or Lugol solution is placed to identify the area to be excised. After in ltrating the vaginal mucosa with 1% xylocaine/epinephrine, a circumferential mucosal incision with a scalpel (#15 blade) is made around the lesion. Next, the vaginal mucosa is dissected away from the endopelvic fascia with Metzenbaum or Struli scissors. Placement of a suture in the incised margin may provide better traction for dissection rather than using toothed forceps for manipulating the lesion, which might denude the mucosa by repetitive grasping. Individual bleeding sites are addressed either by placing hemostatic sutures or cauterization. Closure of the defect is left to the surgeon s discretion, but often these are able to heal spontaneously without the need for closure. Care must be taken to avoid excessive traction or electrocautery of the specimen to allow adequate pathology assessment. Possible surgical complications include hemorrhage, shortening of the vagina, or damage to bladder and/or rectum. In a retrospective study of 105 patients who underwent partial vaginectomy for the treatment of high-grade VAIN, 12% had an underlying malignancy, 22% had negative ndings on nal pathology, and 88% remained without recurrence during a mean follow-up of 25 months.21 Other retrospective series have noted short-term

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respective organizations, only 33 percent reported that a fraud vulnerability review had been recently performed. Additionally, nearly 40 percent of survey participants who thought that their organizations were vulnerable to fraud indicated that their organization lacked a specific policy with respect to reporting fraud.31

So pervasive are the creative contributions of Edison, it is fair to say that if there are patterns of discovery, then Edison made the molds We propose that the hero s journey of our book be centered on three archetypes or patterns of discovery, Serendipity, Proof of Principle, and the 1% Inspiration and 99% Perspiration The Serendipity Pattern is the rst and rarest of the patterns, where pure chance plays a role to produce a discovery even while the inventor is engaged in a prolonged investigation Serendipity is the detection of things through the.

2 Agarwal RC, Aggarwal CC, Prasad VVV A tree projection algorithm for generation of frequent item sets J Parallel Distrib Comput 2001;61(3):350 371 3 Agarwal RC, Aggarwal CC, Prasad VVV Depth rst generation of long patterns Proceedings of Knowledge Discovery and Data Mining; 2000 p 108 118 4 Aggarwal CC, and Yu PS Mining associations with the collective strength approach IEEE Trans Knowledge Data Eng 2001;13(6):863 873 5 Agrawal R, Imielinski T, Swami A Mining association rules between sets of items in very large databases Proceedings of the ACM SIGMOD Conference on Management of Data; 1993 p 207 216 6 Bayardo R, Agrawal R Mining the most interesting rules Proceedings of the 5th KDD San Diego; 1999 p 145 153 7 Birkhoff G Lattice Theory 3rd ed Providence, RI: American Mathematical Society; 1967 8 Brin S, Motwani R, Silverstein C Beyond market baskets: generalizing association rules to correlations.

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