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Foodborne pathogens are the leading causes of approximately 18 million deaths annually in less developed countries, whereas in developed countries foodborne pathogens are responsible for millions of gastrointestinal diseases each year, costing huge amounts of money in terms of lost productivity and medical care Again, new foodborne pathogens are likely to emerge forced by the use of antibiotics and the evolutionary drive of bacteria or fungi Clostridium, Shigella, Salmonella, Listeria monocytogenes, Campylobacter, S aureus, Vibrio spp, and Yersinia enterocolitica are among the most important ones, although many others cannot be excluded as human habits or manufacture practices change Studies on emerging diseases have been a real concern in many scienti c journals through different reviews and have focused mainly on the putative spectrum of different emerging pathogens as well as the epidemiologic reasons for their emergence.

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Dullaghan, N Mookherjee, N Glavas, M Waldbrook, A Thompson, A Wang, K Lee, S Doria, P Hamill, J J Yu, Y Li, O Donini, M M Guarna, B B Finlay, J R North Jr and R E Hancock (2007) Nature Biotechnology 25, 465 472 Shai Y (1995) Trends in Biochemical Sciences 20, 460 464 Shai Y (1999) Biochimica et Biophysica Acta 1462, 55 70 Shi J and A C Camus (2006) Developmental and Comparative Immunology 30, 746 755 Skarnes R C and D W Watson (1957) Bacteriology Reviews 21, 273 294 Smith V J, J M Fernandes, S J Jones, G D Kemp, and M F Tatner (2000) Fish & Shell sh Immunology 10, 243 260 Steiner H, D Hultmark, A Engstrom, H Bennich, and H G Boman (1981) Nature 292, 246 248 Subbalakshmi C and N Sitaram (1998) FEMS Microbiology Letters 160, 91 96..

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Equation (10.15) can be integrated by again applying the method of stationary phase, which yields r p e i(p=4) Hruz (u, l) % 12adi u p2 u2 di u l2 di3 u3 z exp i exp ia (10:16) 3a 4 for uz , aA=4p. Figure 10.6 shows the modulation transfer function for a cubic phase distortion for various values of defocus. As expected, the MTF is relatively insensitive to defocus. With reference to Eqns. (10.14), (6.85), and (4.73), the one-dimensional coherent impulse response for a cubic phase modulation is hr (ux ) x o 1 n ip(uz =l)x2 i(a=l)x3 F e e rect A ldi u (ux =l) (10:17)

The experts who have addressed this problem from only an epidemiologic point of view, but forgetting that microorganisms are subjected to evolutionary avatars, often disagree about the feasibility of predicting and preventing the emergence of new pathogens As many enzybiotics are based on the use of entire bacteriophages that are also subjected to general biological evolution, it follows that one has to take into account these aspects in predicting not only what, but also where or even when a new pathogen will emerge If we can use modern enzybiotics to either facilitate the identi cation and the blocking of pathogens that represent great threats to human kind, or to provide methods for inhibiting the emergence of microbial pathogens, then their use would represent a.

Lemma 10.3 The coe cients of the operator K(z) =

Appl ying freq uency scaling to these values yields the fi nal results:

(q = 0, 1, . . . , L)

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If you re going to create a dedicated space for your podcast production, take some time to think about how you re going to use it. You should consider different studio configurations, depending on how you re going to produce your programming. The simplest is a single operator studio.

On a Windows Vista or Windows 7 system, the scanned le is located in the Pictures\Microsoft Clip Organizer folder on your hard disk, in case you want to use it in some other application that does not support the Clip Organizer. It is assigned a lename that begins with mso (for example, mso414611), and it is saved in JPEG format. Under Windows XP, it is located in My Pictures\Microsoft Clip Organizer.

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