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ways in which the motor system can deteriorate Compulsive, repetitive movements are the most frequent: mouthing movements, stereotyped grimacing, protrusion of the tongue, side-to-side or toand-fro tremor of the head, odd vocalizations such as snif ng, snorting, and bleating In some respects these disorders resemble tics (quasivoluntary movements to relieve tension), but careful observation shows that they are not really voluntary Haloperidol and other drugs of this class have an unpredictable therapeutic effect, seeming at times to bene t the patient only by the superimposition of a drug-induced rigidity Old age is thought always to carry a liability to tremulousness, and indeed, one sees this association with some frequency The head, chin, or hands tremble and the voice quavers, yet there is not the usual slowness and poverty of movement, facial impassivity, or exed posture that would stamp the condition as parkinsonian Some instances of tremor are clearly familial, having appeared or worsened only late in life However, the relation of tremulousness to senility is sometimes open to doubt Charcot, in a review of over 2000 elderly inhabitants of the Salpetriere, could nd only about ` 30 with tremor Some cases probably represent the exaggeration or emergence of essential tremor, but many cases cannot be explained on this basis Spastic or spasmodic dysphonia, a disorder of middle and late life characterized by spasm of all the throat muscles on attempted speech, is discussed on page 428 Blepharoclonus or blepharospasm, an involuntary movement of the eyelids, is also described on page 93

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These have never been fully established From the third decade of life to the beginning of the tenth decade, the average decline in weight of the male brain is from 1394 to 1161 g, a loss of 233 g The pace of this change, very gradual at rst, accelerates during the sixth or seventh decades The loss of brain weight, which correlates roughly with enlargement of the lateral ventricles and widening of the sulci, is presumably the result of neuronal degeneration and replacement gliosis, although this has not been proved The counting of cerebrocortical neurons is fraught with technical dif culties, even with the use of computer-assisted automated techniques (see the critical review of neuron-counting studies by Coleman and Flood) Most studies, point to a depletion of the neuronal population in the neocortex, especially evident in the seventh, eighth, and ninth decades Cell loss in the limbic system (hippocampus, parahippocampal and cingulate gyri) is of special interest in regard to memory Ball, who measured the neuronal loss in the hippocampus, recorded a linear decrease of 27 percent between 45 and 95 years of age Dam reported a similar degree of cell loss and replacement gliosis These changes seem to proceed without relationship to Alzheimer neuro brillary changes and senile plaques (Kemper) However, recent morphologic work, summarized by Albers and also by Morrison and Hof, suggests that cerebral cell loss with aging is less pronounced than previously thought Furthermore, as pointed out by Morrison, the hippocampus may have only minimal cell loss Moreover, this is partially a result of neurogenesis in this region Brain shrinkage is accounted for in part by the reduction in size of large neurons, not their disappearance There is a more substantial reduction in neuronal number in the substantia nigra, locus ceruleus, and basal forebrain nuclei It may be possible to differentiate.

The Event Viewer displays all event logs on Windows NT, 2000, and XP systems Error messages, status reports, and system events, such as startup and shutdown, are displayed in the Event Viewer The user can set the level of messages recorded, and messages can be broken down by type The Event Viewer is very helpful for troubleshooting system problems because it keeps an activity trail of all system events Figure 8-16 shows the Event Viewer and Event Properties on a Windows XP system

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This method supports migration from any Oracle database version on any platform It requires downtime, which for the most part depends on the time it takes to move the data through the network CTAS and IAS methods are single threaded and are not automatically parallelized since the database link is inherently serial when used in a statement However, you can manually parallelize the migration process by initiating multiple CTAS or IAS statements But keep in mind that the overall throughput is limited by the available network bandwidth between the source and the destination This method enables migration of subsets of data, including subsets of schemas and even portions of tables or partitions by using the QUERY clause Consider routing the database links over the InfiniBand or the 10 Gigabit Ethernet network to improve the data transfer rate

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