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Learning Objectives To choose appropriate sampling techniques for a range of biological applications in infrared spectroscopy. To recognize the major infrared bands due to lipids and understand how these may be used to characterize lipid conformation. To recognize the characteristic infrared bands associated with proteins and peptides. To estimate the secondary structure of proteins by applying quantitative analysis of the infrared spectra of such molecules. To recognize the major infrared bands of nucleic acids. To use changes in the infrared spectra of animal tissues to characterize disease. To recognize how infrared methods may be used to differentiate microbial cells. To recognize the common infrared bands observed for plants. To understand how near-infrared methods may be used for quantitative analysis in clinical chemistry.

At the other extreme, knowing only the historical or expected returns and standard deviations of the portfolio may not be very helpful Many market neutral portfolios have nonnormal return distributions, re ecting the presence of options and option-like positions Simple measures of return and variance and calculations based on such measures, including mean-variance analysis and value-at-risk (VAR), may tend to underestimate risks and overestimate returns2 Given a market neutral portfolio s simple historical risk-adjusted returns, however, one may want to look for the following warning signals Are the risk-adjusted returns suspiciously high As Askin Capital Management (ACM) and LTCM showed, some market neutral strategies behave very similarly to short option trades: they tend to experience good returns with suspiciously little risk for some period, and then implode as the result of an unanticipated event.

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Note: All trade summaries include $100 round-turn trade deductions for slippage and commissions. Data source: CQG, Inc.

that can entail unlimited usage of services for a certain period, or then there can be xed prices for certain volumes of usage. It is also possible to charge purely based on volume, which puts the amount of data traf c in the centre of the pricing logic. From an operational point of view it may make sense to charge with this clear cost plus strategy based on network capacity used, but from a consumer point of view it is hard to understand the data traf c amounts required for the services, so this has in general been perceived as a pricing model with dif culties for consumer communication. Figure 2.5 illustrates this fact, as it presents consumer preferences for these different pricing models in a research study carried out by Nokia and NOP in nine different markets across the world. The 24 per cent share of people not wanting to pay for services at all presents loud and clear the challenge for the industry, and these people may be more open towards improved value-based argumentation than overall marketing promotion, because the current value proposition is clearly not striking a chord for this audience. Generally, volume-based pricing is most commonly used for pure GPRS data traf c packages that can be consumed via browsing, emailing, downloading or streaming. Like MMS, the price of GPRS data has come down in 2003 2004, and the new value-based pricing challenges require help for improved service platforms and services management to allow price differentiation of megabytes of data depending on the content, the time of delivery, the delivery mechanism as well as the origin of the

3 Do returns exhibit serial correlation over time When portfolio holdings are illiquid and dif cult to value, managers may be tempted to value portfolio holdings in such a way as to smooth performance and lower volatility Serial correlation of returns may thus re ect portfolio illiquidity and manager manipulation4 What is the portfolio s historical or expected return on assets Return on equity may not be a good indication of performance if the strategy is highly leveraged LTCM boasted a phenomenal return on equity, even as its return on assets was as low as a few cents on the dollar If the strategy is leveraged, is the level reasonable Certain strategies and certain managers may be subject to regulatory control of leverage The US Federal Reserve Board s Regulation T, for example, controls the amount of leverage most investors can use when investing in US.

Per Serving: (1 2 cup/125 ml) Calories 140; Available carbohydrate 17 g; Carbohydrate: 21 g; Fibre 4 g; Fat 4 g; Protein 5 g; Cholesterol 0 mg; Phosphorus 86 mg; Potassium 221 mg; Sodium 326 mg. 1 Serving = 1 Carbohydrate Choice

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