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There is little activity aimed at the improvement of indices of metamerism. For illuminant metamerism, effort is concentrated on the improvement of color difference metrics. For observer metamerism, there seems to be little call for a better metric, despite the aws in the current metric (which is not widely used). This situation could be because it is dif cult enough to address problems of illuminant metamerism to cause the dif culties associated with observer metamerism to be considered of second order at this time.

other materials from packaging may deactivate or denature therapeutic peptide and proteins Further, peptides and proteins have a tendency to adsorb on to the surface of container closure systems, thereby removing virtually all active material from the drug formulation Even when the drug desorbs back into the solution, the interaction could result in loss of potency Lyophilized biopharmaceutical products can be affected by moisture if the seal is not adequate to prevent ingress of moisture into the container Thus packaging can make and break nal formulation of lyophilized product Vials that are not designed speci cally for lyophilization (with convex rather than at bottoms) can make the lyophilization process less ef cient Rubber closures can also hinder freeze drying if they do not permit adequate venting during sublimation.

1100 Temperature (K)

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You can have up to 256 layouts, including the model tab. To create a new layout, right-click an existing layout tab to open the shortcut menu. The shortcut menu options help you to manage layouts: New layout: Creates a new layout tab. From template: Opens the Select File dialog box in which you can choose a .dwg, .dxf, or .dwt file. Click Open. You can then choose the layout or layouts that you want from the Insert Layout(s) dialog box. When you import a template, you import everything that exists on the paper space layout, including viewports, any existing text, the title block, and so on. (You can then get rid of anything you don t want, if necessary.)

a core diameter of 50 mm, a numerical aperture of 0.22, and a length of 10 m. After two additional ampli er passes, the initial beam quality is reproduced (see Fig. 4.31) and the beam is extracted with help of the optical isolation. Applying the four-pass scheme to the serial ampli er arrangement, an average output power up to 31 W has been achieved at a 10-kHz repetition rate. Figure 4.30 shows the measured output power as a function of the oscillator power. Currently, output power scaling about 100 W is under development. In addition, two further pumping chambers are to be used. This new setup is shown in Fig. 4.32. After the second ampli cation pass, the beam is re ected using a conventional HR

Stopper rubbers adsorb and desorb moisture at different rates and under storage conditions stoppers that were not properly dehydrated can release water into lyophilized product Another source of instability of biopharmaceutical products traceable to packaging is silicone oil, which is commonly used to lubricate elastomeric stoppers during ll/ nish to facilitate insertion of the stopper into the vial Silicone oil is known to inactivate protein through nucleation of protein around oil droplets The problem is being circumvented by using a uoroelastomer coating on stoppers to provide the needed lubricity in addition to chemical innertness, barrier protection, and safety [148] The uoroelastomer lms reduce adsorption of drug on to the stopper, provide lubricity for proper vial sealing, and also reduce the possibility of extractables migrating from the rubber stopper into the product The pre lled syringes are becoming very popular in the injectable markets.

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