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The student understands the structural makeup of the kidneys, their blood supply, and the relation between major functional components Y Defines the gross structures and their interrelationships: renal pelvis, calyces, renal pyramids, renal medulla (inner and outer zones), renal cortex, and papilla Y Defines the components of the nephron and their interrelationships: renal corpuscle, glomerulus, nephron, and collecting-duct system Y Draws the relationship between glomerulus, Bowman s capsule, and the proximal tubule Y Describes the 3 layers separating the lumen of the glomerular capillaries and Bowman s space; defines podocytes, foot processes, and slit diaphragms Y Defines glomerular mesangial cells and states their functions and location within the glomerulus Y Lists the individual tubular segments in order; states the segments that comprise the proximal tubule, Henle s loop, and the collecting-duct system; defines principal cells and intercalated cells Y Lists, in order, the vessels through which blood flows from the renal artery to the renal vein; contrasts the blood supply to the cortex and the medulla; defines vasa recta and vascular bundles Y Describes, in general terms, the differences among superficial cortical, midcortical, and juxtamedullary nephrons Y Defines juxtaglomerular apparatus and describes its 3 cell types; states the function of the granular cells The student understands how the 2 kidneys handle substances in order to achieve balance of each Y Defines the basic renal processes: glomerular filtration, tubular reabsorption, and tubular secretion Y Defines renal metabolism of a substance and gives examples

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CHAPTER 6:

Although renal physiologists traditionally list glomerular filtration, tubular reabsorption, and tubular secretion as the 3 basic renal processes, we cannot overlook metabolism by the tubular cells For example, the tubular cells may extract organic nutrients from the glomerular filtrate or peritubular capillaries and metabolize them as dictated by the cells own nutrient requirements In doing so, the renal cells are behaving no differently from any other cells in the body In contrast, other metabolic transformations performed by the kidney are not directed toward its own nutritional requirements but rather toward altering the composition of the urine and plasma The most important of these are the synthesis of ammonium from glutamine and the production of bicarbonate, both described in 9

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CHAPTER 7:

reNaL FUNCtIONS, aNatOMY, aND BaSIC prOCeSSeS / 21

CHAPTER 8:

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CHAPTER 9:

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By far, the most difficult aspect of renal physiology for students (and authors alike) is regulation of renal function Neural signals, hormonal signals, and intrarenal chemical messengers combine to regulate the basic renal processes presented previously in a manner to help the kidneys meet the needs of the body Unfortunately, our collective knowledge on much of this is, as yet, incomplete Of necessity, much of the coverage in this textbook will attempt to draw an overview of renal function without an emphasis on nuance and detail that is more appropriate for advanced texts As with many organs, signals regulating the kidney arise from both neural and hormonal input Neural signals originate in the sympathetic celiac plexus Sympathetic signals exert major control over renal blood flow, glomerular filtration, and the release of vasoactive substances (the renin-angiotensin system, described later) Hormonal signals originate in the adrenal gland, pituitary gland, and heart The adrenal cortex secretes the steroid hormones aldosterone and cortisol, and the adrenal medulla secretes the catecholamines epinephrine and norepinephrine All of these hormones, but mainly aldosterone, are regulators of sodium and potassium excretion by the kidney The pituitary gland secretes the hormone arginine vasopressin (also called ADH) ADH is a major regulator of water excretion, and via its influence on the renal vasculature and possible collecting-duct principal cells, probably sodium excretion as well The heart secretes hormones, natriuretic peptides, that contribute to signaling increased excretion of sodium by the kidneys The most difficult aspect of regulation lies in the realm of intrarenal chemical messengers (ie, messengers that originate in one part of the kidney and act in another part) It is clear that an array of substances (eg, nitric oxide, purinergic agonists, superoxide, various eicosanoids) influence basic renal processes, but, for the most part, the role of these substances is beyond the scope of this text.

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EPILOGUE:

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