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As explained earlier, the agency must make difficult decisions regarding what additional data will be required to approve a therapy that is improved by nanotechnology There are several reasons why it may be more difficult for the FDA to maintain scientific expertise in nanotechnology than past and other emerging technologies First, nanotechnology is unique in that it will touch virtually every aspect of modern medicine As one scholar put it, [T]he difference between nanotechnologists and biotechnologists is that the former do not restrict themselves to biological limitations like the latter, and they are much more ambitious about the kinds of accomplishments that they want to achieve 100 Unlike other past and emerging trends in medical products, nanomedical products will be evaluated by every Center at the FDA; often different Centers will be forced to review similar products.

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For example, CBER will be primarily responsible for evaluating the efficacy and safety of dendrimers in gene therapy while CDER and CDRH will review dendrimers as drug delivery vehicles This is different from other emerging technologies where a particular center could establish expertise in a particular area of research Because CBER was handed the responsibility of regulating nearly all biotechnology products, it was able to develop expertise in the area and develop a working relationship with the biotechnology industry Staff became intimately familiar with products, ongoing research, and industry players while manufacturers became acquainted with the reviewers, procedures, and requirements of CBER Division of responsibility to enhance expertise may not be possible with nanomedicine, where every Center will be faced with review of nanoproducts Second, it may be more difficult for the FDA to acquire staff with an expertise in nanomedicine than other past and emerging technologies.

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<transaction <transaction <transaction <transaction <transaction <transaction date="2001 03 01" date="2001 03 01" date="2001 03 03" date="2001 03 09" date="2001 03 10" date="2001 03 15" type="DD" type="DD" type="CR" type="SO" type="WD" type="CR" payee="TV License">8.91</transaction> payee="British Gas">22.00</transaction> payee="Client">400.00</transaction> payee="Rent">633.00</transaction> payee="Cash">50.00</transaction> payee="Interest">0.58</transaction>

There are still relatively few experts in this burgeoning field And as the field begins to take flight in the near future, the most qualified scientists will be lured away by the higher salaries and stock options offered by industry..

52 Arti Rai, Fostering Cumulative Innovation in the Biopharmaceutical Industry: The Role of Patents and Antitrust, 16 Berkeley Tech LJ 813, 834 (Spring 2001) 53 Michael Heller & Rebecca S Eisenberg, Can Patents Deter Innovation The Anticommons in Biomedical Research, 280 Sci 698, 701 (May 1998) (noting that acrimonious licensing negotiations are particularly likely in biotechnology research because the negotiating parties are often scientists who may overestimate the value of their work) 54 See Suzanne Scotchmer, Standing on the Shoulders of Giants: Cumulative Research and the Patent Law, 5 J Econ Perspect 29, 32 (1991) ( A second inventor who cannot market the next generation product without a license has a very weak bargaining position.

progress ratio (Stojmenovic, 2006), to establish a migration path from the discoverer to the replacement proxy, and, meanwhile, the intermediate nodes along this path shift their position toward the failed A-node. More speci cally, after sending the action message, the discoverer moves to the failure node s position, while intermediate nodes move to the position of their prior hop after forwarding the action message. After receiving the action message, the replacement proxy rst informs the replacement node to ll its current position and then itself moves toward the location of its prior hop.

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