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and after weeks 4 and 10 For a period of 10 weeks, 9 volunteers ingested 40 g of tomato paste with 10 g of olive oil while 10 controls ingested olive oil only Carotenoid levels were equivalent between the two groups at the beginning of the study and there were no significant differences between the groups at week 4 There was neither change in serum carotenoids in the control group by week 10 nor in other carotenoids but lycopene in the experimental group, but those consuming tomato paste exhibited higher serum levels of lycopene accompanied by scapular erythema development 40% less than controls40 In subsequent experiments that involved daily ingestion of tomato paste (16 mg/d) for 10 weeks, Stahl and Sies demonstrated similar results, with increases measured in serum levels of lycopene and total carotenoids in skin and significantly less erythema formation after 10 weeks They also determined that there is an optimal level of protection associated with each carotenoid micronutrient41 In a placebo-controlled, parallel study involving some of the same investigators, the protective effects against erythema of beta-carotene (24 mg/d) were compared to those of the same dose of a carotenoid combination of beta-carotene, lutein, and lycopene (8 mg/d each) or placebo for 12 weeks Erythema intensity before and 24 hours after irradiation with a solar light simulator was recorded at baseline and following 6 and 12 weeks of supplementation Researchers noted diminished intensity in erythema 24 hours after exposure (at weeks 6 and 12) in both experimental groups, with substantially less erythema formation after 12 weeks in comparison to baseline While there were no observed changes in the control group, serum carotenoid levels increased significantly also, three- to four-fold in the betacarotene group and one- to three-fold in the mixed carotenoid group42 In a more

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EGI compared the bills-of-material for two frames that were treated as entirely separate assemblies They discovered the two frames shared all but four parts in common, and three of the four different parts added no form, function, or feature to the frame By comparing the bills-of-material for different products, EGI was able to find areas of commonality that could potentially be exploited to simplify product design and manufacture (which reduces non-valueadd work and will translate into improved PCE)

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recent study by several of the same investigators, the photoprotective effects of synthetic lycopene were compared to the effects of a tomato extract (Lyc-o-Mato) and a beverage containing solubilized Lyc-o-Mato (Lyc-o-Guard-Drink) after 12 weeks of supplementation Significant increases were observed in all groups in terms of serum levels of lycopene and total skin carotenoids and a protective effect against erythema formation was seen in all groups as well, but it was substantially larger in the Lyco-o-Mato and Lyc-o-Guard groups The researchers speculated that the carotenoid phytofluene and carotenoid precursor phytoene may have assisted in providing this additional photoprotection43 Finally, lutein and zeaxanthin, found in leafy green vegetables, were supplemented for 2 weeks in the diets of female hairless Skh-1 mice to determine the cutaneous response to UVB Investigators observed significant reductions in the edematous cutaneous response as well as decreases in the UVB-induced elevation in hyperproliferative markers44

This kind of information is not as easy to come by in services, so you ll have to do more digging Try comparing the types of paperwork used in different processes, commonality in the software applications, common process steps (perhaps revealed in the value stream map), and so on

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Comprising a broad range of more than 8000 naturally-occurring compounds, polyphenols are secondary plant metabolites that exert varying degrees of antioxidant activity All of these diverse substances share a definitive structural component, a phenol or an aromatic ring with at least one hydroxyl group Polyphenols are an exceedingly important part of, and the most copious antioxidants in, the human diet, and found in a vast spectrum of vegetables, fruits, herbs, grains, tea, coffee beans, propolis, and red wine45,46 (Table 8-1) Flavonoids are the most abundant polyphenols in the human diet as well as the most studied polyphenols, and can be further divided into several categories These subclasses include flavones

How can the information gained from the substructure analysis impact process PCE Recall that N, the number of products in the process, and A, the number of activities in the process, are both prime drivers of PCE

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