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362 National Institute of General Medical Sciences (NIGMS), 93 National Institutes of Health (NIH), 29, 149 150. See also NIH entries funding for, 90 funding of research by, 300 302 Native Americans, 69, 70, 252. See also American Indians Nazi malaria experiments, 198 Negative predictive value (NPV), 169 171 Negligence, standards of, 191 Negligence theory, 200 Neuroendocrine tumors, 145 Neurological disease, 194 195 Niblack, John, 129 Niche drug developers, 126 Niche markets, 128 130 Niche therapeutic categories, 233 NIH-DOE Working Group on Ethical, Legal, and Social Implications (ELSI) of Human Genome Research, 179 NIH Reauthorization Act, 301, 303 Noncoding sequences, 42 Noncompetition agreements, 120, 121 Nondisclosure agreements, 121 Nondiscrimination legislation, 18, 22 Non-Mendelian inheritance, 37 North American Regional Committee of the Human Genome Diversity Project (HGDP), 69 founding document of, 77 78 Nsiah-Jefferson, Laurie, 267 Nucleotide sequences, 34 Nunnally, Allen C., 109 Nuremberg Code, 197 199 Occupational exposure, 153 Off-label use, 108, 202, 327 Of ce of Minority Health Care, 303 Of ce of Post-Marketing Drug Risk Assessment (OPDRA), 92, 94, 324 Of ce of Postmarketing Surveillance, 85 Of ce of Women s Health, 303 Omenn, Gilbert S., 137 -omics projects, 30 31, 45 Oncology, 153

void CCode3AView::OnDraw(CDC* pDC) { CCode3ADoc* pDoc = GetDocument(); ASSERT_VALID(pDoc);

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generates an error because it is not clear if 100 is a part of the instructions to specify the number of shares or the execution instruction (the price at which the order should be placed). A correct statement might read:

General development and CNS Promising practice (Haynes function et al., 2003; Lai et al., 2002; Ribas-Fito et al., 2001) Correcting oxygenation levels Promising practice (R. A. M. (e.g., those compromised due to Myers, Snyder, & Emhoff, carbon monoxide) 1995; Thom & Kelm, 1989; Thom et al., 1995)

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which measures co-movement of the excess return on two securities, x1t and x2t, over time. As seen in the formula, if security 1 and 2 are both above their respective means, the term in the summation at time t is positive and hence time t makes a positive contribution to the covariance. If the two securities are both below their means, (x1t - m1) is negative and (x2t - m2) term is also negative. Since their products remain positive, the cov1,2 term makes a positive contribution at time t and the covariance is increased. Only if one security moves above its mean, and one security moves below its mean at the same time, the product is negative and covariance cov1,2 is decreased. This covariance (2.2.2) is the key to diversi cation. If the securities move in opposite directions, then volatility of the portfolio is lowered as the lows of one security are offset by highs of the other. However, we emphasize that the two assets don t have to be negatively correlated with each other for diversi cation to take place from a portfolio combining the two. Consider the following hypothetical portfolio equally weighted between two assets: Portfolio = wx1 + (1 - w) x2 = 0.5 x1 + 0.5 x2 (2.2.3)

Openmoko5 is an open source, Linux-based platform (see Figure 7.2 for an architecture diagram) speci cally focused on selling the hackable Neo range of phones. The idea behind the Neo is to develop open source hardware, as well as software. As of March 2009, there are at least 10 different distributions (including Android, Debian, Gentoo, etc.) that can run on Neo phones, as well as a variety of Openmoko software distributions. Openmoko has succeeded in producing a good base of packages covering the main functionality we have come to expect from mobile phones and to develop, produce and market a phone based on their software stack. The Openmoko community appears to be very active and development seems to progress rapidly. The challenge is the extremely small production volumes of Neo phones success is unlikely without entering the mass market.

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