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Solution to Exercise 18-3. Create a Windows application that calculates sales tax for a given amount. The user can enter an amount in a text box, and then can enter a sales tax between 0 and 25%, in increments of 0.25%. When the user clicks the Submit

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Freckles (ephelides) and lentigines are flat brown spots Freckles first appear in young children, darken with ultraviolet exposure, and fade with cessation of sun exposure In adults, depending on the fairness of the complexion, flat brown spots (lentigines), often with sharp borders, gradually appear in sun-exposed areas, particularly the dorsa of the hands They do not fade with cessation of sun exposure They should be evaluated like all pigmented lesions: If the pigmentation is homogeneous and they are symmetric and flat, they are most likely benign Solar lentigines, also called liver spots, can be treated with topical 01% tretinoin, tazarotene 01%, 2% 4-hydroxyanisole with tretinoin 001% (Solage), laser therapy, and cryotherapy

Primary malignant melanomas may be classified into various clinicohistologic types, including lentigo maligna melanoma (arising on chronically sun-exposed skin of older individuals); superficial spreading malignant melanoma (two-thirds of all melanomas arising on intermittently sun-exposed skin); nodular malignant melanoma; acral-

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of intermediate-risk and high-risk patients to centers with expertise in melanoma is strongly recommended

Miller AJ et al Melanoma N Engl J Med 2006 Jul 6;355(1):51 65 [PMID: 16822996] Morton DL et al; MSLT Group Sentinel-node biopsy or nodal observation in melanoma N Engl J Med 2006 Sep 28;355 (13):1307 17 [PMID: 17005948] Thompson JF et al Case records of the Massachusetts General Hospital Case 2-200 pigmented lesion on the arm N Engl J Med 2007 Jan 18:356(3):285 92 [PMID: 17229956]

button, the tax is calculated, and both the tax and the total are output in a label. The application should look something like Figure A-7 when it runs.

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lentiginous melanomas (arising on palms, soles, and nail beds); malignant melanomas on mucous membranes; and miscellaneous forms such as amelanotic (nonpigmented) melanoma and melanomas arising from blue nevi (rare) and congenital nevi Clinical features of pigmented lesions suspicious for melanoma are an irregular notched border where the pigment appears to be leaking into the normal surrounding skin; a topography that may be irregular, ie, partly raised and partly flat Color variegation is present, and colors such as pink, blue, gray, white, and black are indications for referral The American Cancer Society has proposed the mnemonic ABCD = Asymmetry, Border irregularity, Color variegation, and Diameter greater than 6 mm E for Evolution can be added The history of a changing mole (evolution) is the single most important historical reason for close evaluation and possible referral Bleeding and ulceration are ominous signs A mole that stands out from the patient s other moles deserves special scrutiny, ugly duckling sign A patient with a large number of moles is statistically at increased risk for melanoma and deserves careful and periodic examination, particularly if the lesions are atypical Referral of suspicious pigmented lesions is always appropriate While superficial spreading melanoma is largely a disease of whites, persons of other races are at risk for other types of melanoma, particularly acral lentiginous melanoma These occur as dark, sometimes irregularly shaped lesions on the palms and soles and as new, often broad and solitary, darkly pigmented longitudinal streaks in the nails Acral lentiginous melanoma may be a difficult diagnosis because benign pigmented lesions of the hands, feet, and nails occur commonly in more darkly pigmented persons and clinicians may hesitate to biopsy the palms, soles, and nail beds As a result, the diagnosis is often delayed until the tumor has become clinically obvious and histologically thick Clinicians should give special attention to new or changing lesions in these areas Dermoscopy use of a special magnifying device to evaluate pigmented lesions helps select suspicious lesions that require biopsy In experienced hands, the specificity is 85% and the sensitivity 95%.

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SCALING DISORDERS ATOPIC DERMATITIS (ECZEMA)

Figure A-7. Your goal for Exercise 18-3.

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