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The second approach is typically superior For the overhead of the o set array, we get direct access to any eld We also get a clean way to deal with null values A null value is a special value used to denote that the value for a eld is unavailable or inapplicable If a eld contains a null value, the pointer to the end of the eld is set to be the same as the pointer to the beginning of the eld That is, no space is used for representing the null value, and a comparison of the pointers to the beginning and the end of the eld is used to determine that the value in the eld is null Variable-length record formats can obviously be used to store xed-length records as well; sometimes, the extra overhead is justi ed by the added exibility, because issues such as supporting null values and adding elds to a record type arise with xed-length records as well Having variable-length elds in a record can raise some subtle issues, especially when a record is modi ed Modifying a eld may cause it to grow, which requires us to shift all subsequent elds to make space for the modi cation in all three record formats presented above A record that is modi ed may no longer t into the space remaining on its page If so, it may have to be moved to another page If rids, which are used to point to a record, include the page number (see Section 76), moving a record to another page causes a problem We may have to leave a forwarding address on this page identifying the new location of the record And to ensure that space is always available for this forwarding address, we would have to allocate some minimum space for each record, regardless of its length A record may grow so large that it no longer ts on any one page We have to deal with this condition by breaking a record into smaller records The smaller.

2V(1 - X - PD) N(2A+1)S (2*03) [1 - 05 - (01*10)] 4 [(2*3)+1] 2

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such as cinnamic alcohol and aldehyde, may no longer be able to tolerate the fragrance-preservative chemical benzyl alcohol because of cross-reactivity The fragrance -allergic patient may then, in an attempt to avoid fragrances, turn to fragrance-free products, which notably may contain the fragrance benzyl alcohol Indeed, fragrance-based chemicals may be added to products labeled as fragrance-free if they are included for an indication other than as a fragrance Benzyl alcohol has a preservative function as well as a fragrance function and can therefore be found in fragrancefree products In this example, the patient using a benzyl alcohol-containing fragrance-free product could end up with recall-type reactions in the distributions of other fragrance sensitivity responses This may occur in addition to or without a subsequent dermatitis in the area of the new fragrance-free product Obviously, a diagnosis in this case would be difficult to achieve As with any ACD, factors to consider in attempting to correlate exposure with reactions and control future outbreaks are (1) the number and duration of exposures to the same chemical (even if it is in a different product composition); (2) status of the skin barrier; (3) occlusion; and (4) the amount (dose) per unit area of skin exposed2

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whether an answer row is to be generated for a given group Therefore, a column appearing in the group-quali cation must appear as the argument to an aggregation operator, or it must also appear in grouping-list If the GROUP BY clause is omitted, the entire table is regarded as a single group

fragrances contact dermatitis and, 138 140 demographics and significance, 325 FM I/II and 26 fragrances required to be labeled in Europe, 327 Fragrance Mix I (FM I), 325 326 Fragrance Mix II (FM II), 326 Lyral, 326 327 free radicals See also antioxidants in anti-inflammatory agent, 314 role in photoaging, 39 theory of aging, 292 G Gelatinases, 26 genistein, 303 304 gentisic acid, 281 ginseng, 318 glabridin, 281 Glogau Photoaging Classification, 344 glucosamine, 55 glutathione antioxidant, 297 glycation collagen, 8 9 extracellular matrix (ECM), 8 glycerin, 275 glycolic acid, 149 glycoproteins (GP), 11 glycosaminoglycans (GAGs) dermis and, 11 skin aging characteristic, 38 39 granular layer (stratum granulosum), 4 granulomatous rosacea, 130 grape seed extract, 301 302 green tea antioxidant, 299 molecular mechanisms, 299 photoprotection by green tea, 299 use in humans, 299 300 as depigmenting agent, 285 Griffith s Photonumeric Scale, 345 growth factors differentiative, 5 skin immunology aspects of, 22 EGF, 23 24 TGF, 23 24 H hair growth botulinum toxin (BTX) and, 185 sex hormones and, 30 removal, laser-based, 216 skin of color and African hair, 116 Asian hair, 116 Caucasian hair, 116 Hamilton scale, 344 headaches, 183 Helicobacter pylori, 128 See also rosacea (type 2 sensitive skin) high-density lipoprotein (HDL), 16 histamine, 313 314 hormone replacement therapy (HRT) aging skin and, 31 cigarettes and aging skin study, 42 estrogen, 32 for skin aging, 32 horny layer (SC), 4 5 horse chestnut seed extract, 55 humectants See under moisturizing agents hyaluronic acid (HA), 10 11, 55

Easy calculation of PCE To use the basic PCE equation, PCE = Value-Add Time / Total Lead Time, start by determining how long it takes any work item to make it all the way through the process (= total lead time) You can get a sample of actual lead times by tracking individual work items through the process (attaching tags onto materials or paperwork that people will stamp at each work station, for example) or looking at email dates on service items Or you can get an overall estimate of the average lead time using Little s Law by counting up all the Things-in-Process and dividing by the average completion rate:

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