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Complexity reduction reached its first milestone in the early part of the twentieth century Henry Ford was just starting his automobile career by failing in two ventures targeted at building fancy cars (one of which later became Cadillac) At the time, cars were the toys of the rich the volume leader in 1908 was the luxurious Buick President Woodrow Wilson decried the conspicuous display as a mark of class distinction and an encouragement to the growth of Socialism Ford saw the unfilled need for utility transportation for the masses, and the Model T was born, available in any color you want so long as it is black The Model T, the ultimate in product simplicity, resulted in low cost due to vertically integrated production in stupendous volumes and made Ford the richest man in the world He was able to transform iron ore into an automobile in just 33 hours Table 1A shows Ford s financial results:
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and coiling of elastic fibers in the papillary dermis distinguish the alterations induced by UV exposure Continued UV exposure leads to these same changes in the reticular dermis29 Electron microscopy examination of the elastic fibers reveals an increase in the complexity of the shape and arrangement of the fibers, a decrease in the number of microfibrils, a higher number of electron-dense inclusions, and more interfibrillar areas30 Elastin extracted from the skin of elderly patients has been shown to contain small amounts of sugar and lipids and an abnormally high level of polar amino acids3 The mechanism of these changes is not as well understood as it is in collagen; however, MMPs likely play a role because MMP-2 has been shown to degrade elastin31 It is known that the initial response of elastic fibers to photodamage is hyperplastic, resulting in increased elastic tissue The magnitude of this response depends on the degree of sun exposure The second phase of response, seen in aged elastic fibers, is degenerative, resulting in reduced elasticity and resiliency of the skin32,33 Aged skin that has suffered this degenerative response manifests an alteration in the normal pattern of immature elastic fibers, called oxytalan, which are found in the papillary dermis In young skin, these fibers form a network that ascends perpendicularly from the uppermost portion of the papillary dermis to just below the basement membrane (Fig 2-5 in 2) As skin ages, this network gradually disappears34 In fact, a loss of skin elasticity has been shown to incrementally increase with age35 This loss of elasticity may account for much of the sagging often seen in the skin of elderly individuals GLYCOSAMINOGLYCANS Glycosaminoglycans (GAGs) are important molecules because they can bind water up to 1000 times their volume The GAG family includes hyaluronic acid (HA), chondroitin sulfate, and dermatan sulfate, among many other constituents Numerous studies report that GAGs, especially HA, are decreased in amount in photoaged skin36 However, some conflicting studies report no change in the amount of GAGs in aged skin37 A study by Uitto demonstrated that photoaged skin exhibits a reduction in HA and an increase in chondroitin sulfate proteoglycans,38 which, interestingly, is a pattern also seen in scars In young skin, the HA is found at the.
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