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Beta-carotene is a member of the carotenoid family, highly pigmented (red, orange, yellow), lipid-soluble substances naturally present in several fruits, grains, oils, and vegetables (such as apricots, carrots, green peppers, spinach, squash, and sweet potatoes) Notably, in a systematic study of antioxidants in dietary plants, carrots were found to have the lowest content of antioxidants of the array of roots and tubers screened84 Because it can be converted into active vitamin A (retinol), beta-carotene is a provitamin, as are alpha- and gamma-carotene Betacarotene has received substantially more attention than the other carotenoid compounds because it has been shown to contribute much more to human nutrition as compared to its related substances68 In 2006, Stahl and Krutmann reported that the systemic use of beta-carotene in dosages of 15 to 30 mg/d for 10 to 12 weeks had been shown to impart protection against UV-induced erythema, but was insufficient in terms of offering full

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The use of the Arnica montana plant has been promoted by homeopathic practitioners for hundreds of years Arnica is used as a supplement for its antiinflammatory properties, which have been attributed to its constituent sequiterpene lactones87 Its primary skin care application is in the treatment and prevention of bruises (see 21) While taking arnica regularly offers little benefit to the skin, the author suggests it to patients before cosmetic procedures such as soft tissue augmentation Four homeopathic arnica pills labeled with 30x dilution taken 4 to 6 hours before a cosmetic procedure is recommended In a recent double-blind study of 29 patients given perioperative homeopathic A montana or placebo after undergoing rhytidectomy, smaller areas of ecchymosis were measured on the 4

Memory in a computer system is arranged into primary storage (cache and main memory), secondary storage (magnetic disks), and tertiary storage (optical disks and tapes) Storage devices that store data persistently are called nonvolatile (Section 71) Disks provide inexpensive, nonvolatile storage The unit of transfer from disk into main memory is called a block or page Blocks are arranged on tracks on several platters The time to access a page depends on its location on disk The access time has three components: the time to move the disk arm to the desired track (seek time), the time to wait for the desired block to rotate under the disk head (rotational delay), and the time to transfer the data (transfer time) (Section 711) Careful placement of pages on the disk to exploit the geometry of a disk can minimize the seek time and rotational delay when pages are read sequentially (Section 712) A disk array is an arrangement of several disks that are attached to a computer Performance of a disk array can be increased through data striping and reliability can be increased through redundancy Di erent RAID organizations called RAID levels represent di erent trade-o s between reliability and performance (Section 72) In a DBMS, the disk space manager manages space on disk by keeping track of free and used disk blocks It also provides the abstraction of the data being a collection of disk pages DBMSs rarely use OS les for performance, functionality, and portability reasons (Section 73)

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protection against UVR89 More recently, investigators reviewed the literature up to June 2007 in PubMed, ISI Web of Science, and the epidermolysis bullosa acquisita Cochrane Library in conducting a metaanalysis of supplementation studies of dietary beta-carotene as protection against sunburn Meta-analysis of the seven studies identified revealed that beta-carotene supplementation did indeed confer protection against sunburn in a time-dependent fashion, with a minimum of 10 weeks of supplementation necessary90 Indeed, in September 2007, Stahl and Sies clarified that dietary carotenoids such as beta-carotene and lycopene, as well as flavonoids, contribute to the prevention of UV-induced erythema formation after ingestion and dispersal to light-exposed areas, including the skin and eyes Specifically, these micronutrients reduced sensitivity to UVinduced erythema in volunteers after 10 to 12 weeks of dietary intervention91 Clearly, there are limits to the protection afforded by beta-carotene In a large-scale randomized, double-blind, placebocontrolled 12-year primary-prevention trial of beta-carotene supplementation with follow-up, investigators found that supplementing with 50 mg of betacarotene on alternate days in apparently healthy male physicians from 40 to 84 years of age in 1982 (n 22,071) did not influence the development of a first basal cell or squamous cell carcinoma92 It is worth noting that beta-carotene supplementation has been demonstrated to contribute to elevating the risk of developing lung cancer in smokers and those exposed to asbestos93 There are minor risks inherent in taking too much beta-carotene and other provitamin A compounds Superficially, the tint of one s skin can be rendered more yellow by consuming

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