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10 Thornton MJ, Taylor AH, Mulligan K, et al Oestrogen receptor beta is the predominant oestrogen receptor in human scalp skin Exp Dermatol 2003;12: 181-190 11 Pelletier G, Ren L Localization of sex steroid receptors in human skin Histol Histopathol 2004;19:629-636 12 Pedersen SB, Brunn JM, Hube F, et al Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: influences of adipose cell differentiation on fat depot localization Mol Cell Endocrinol 2001;182:27-37 13 Ashcroft GS, Greenwell-Wild T, Horan MA, et al Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response Am J Pathol 1999;155:1137-1146 14 Kanda N, Watanabe S Regulatory roles of sex hormones in cutaneou biology and immunology J Dermatol Sci 2005; 38: 1-7 15 Dekkers OM, Thio BH, Romijn JA, et al Acne vulgaris: endocrine aspects Ned Tijdschr Geneeskd 2006;150:1281-1285 16 Trueb RM Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women Dermatology 2004;209:202-207 17 Sawaya ME, Price VH Different levels of 5-alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia J Invest Dermatol 1997; 109:296-300 18 Affinito P, Palomba S, Sorrentino C, et al Effects of postmenopausal hypoestrogenism on skin collagen Maturitas 1999;33:239-247 19 Brincat M, Versi E, Moniz CF, et al Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy Obstet Gynecol 1987; 70:123-127 20 Patriarca MT, Goldman KZ, Dos Santos JM, et al Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: a pilot study Eur J Obstet Gynecol Reprod Biol 2007;130:202-205 21 Sauerbronn AV, Fonseca AM, Bagnoli VR, et al The effects of systemic hormonal replacement therapy on the skin of postmenopausal women Int J Gynaecol Obstet 2000;68:35-41 22 Castelo-Branco C, Buran M, GonzalezMerlo J Skin collagen changes related to age and hormone replacement therapy Maturitas 1992;15:113-119 23 Brincat M, Versi E, O Dowd T, et al Skin collagen changes in postmenopausal women receiving oestradiol gel Maturitas 1987;9:1-5.

sequence, and for what specific benefit in terms of value-creation-atstake (expressed in predicted gains in Economic Profit) The top priorities are often represented in a value agenda chart like that shown in Figure 81 They are called agendas because they show the sequence in which specific projects or efforts will be implemented The size of the estimated value creation and prioritized sequence of initiatives will vary from company to company

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24 Pi rard-Franchimont C, Letawe C, Gofin V, et al Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study Maturitas 1995; 22:151-154 25 Harvell J, Hussona-Saeed I, Maibach HI Changes in transepidermal water loss and cutaneous blood flow during the menstrual cycle Contact Dermatitis 1992;27: 294-301 26 Creidi P, Faivre B, Agache P, et al Effect of a conjugated oestrogen (Premarin) cream on aging facial skin A comparative study with a placebo cream Maturitas 1994; 19:211-223 27 Fuchs KO, Solis O, Tapawan R, et al The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study Cutis 2003;71:481-488 28 Zouboulis CC, Boschnakow A Chronological aging and photoaging of the human sebaceous gland Clin Exp Dermatol 2001;26:600-607 29 Dieudonne MN, Pecquery R, Boumediene A, et al Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids Am J Physiol 1998;274: C1645-C1652 30 Dieudonne MN, Leneveu MC, Giudicelli Y, et al Evidence for functional estrogen receptors alpha and beta in human adipose cells: regional specificities and regulation by estrogens Am J Physiol Cell Physiol 2004;286:C655-C661 31 Ashcroft GS, Dodsworth J, van Boxtel E, et al Estrogen accelerates cutaneous wound healing associated with an increase in TGFbeta1 levels Nat Med 1997;3:1209-1215 32 Margolis DJ, Knauss J, Bilker W Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers Lancet 2002;359:675-677 33 Gilliver SC, Wu F, Ashcroft GS Regulatory roles of androgens in cutaneous wound healing Thromb Haemost 2003; 90:978-985 34 Fimmel S, Zouboulis CC Influence of physiological androgen levels on wound healing and immune status in men Aging Male 2005;8:166-174 35 Adzick NS, Lorenz HP Cells, matrix, growth factors, and the surgeon The biology of scarless fetal wound repair Ann Surg 1994;220:10-18 36 Chau D, Mancoll JS, Lee S, et al Tamoxifen downregulates TFG-beta production in keloid fibroblasts Ann Plast Surg 1998;40:490-493 37 Mikulec AA, Hanasono MM, Lum J, et al Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts Arch Facial Plast Surg 2001;3:111-114.

A Complexity Value Agenda depicts predicted gains from specific process- and offering-related improvements as measured through likely impact on EP The improvement efforts are shown in order from the biggest to smallest gains which is often the order in which they will be implemented with the total value-at-stake in a final bar These graphical representations of Complexity Value Agendas are good communication tools that help launch first-wave complexity and process improvement projects

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