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binary counter does not cause the JK ip- ops to reset at exactly the same time on account of different propagation delays, then the binary word appearing at the output of the counter will change from 1001 to some other number, and the output of the four-input NAND gate will no longer be high In such a condition, the ip- ops that have not already reset will then not be able to reset, and the counting sequence will be irreparably compromised What can be done to obviate this problem The answer is to use a systematic approach to the design of sequential circuits making use of state transition diagrams This topic will be discussed in the next section A simple implementation of the binary counter we have described in terms of its functional behavior is shown in Figure 1412 The gure depicts a three-bit binary ripple counter, which is obtained from a cascade of three JK ip- ops The transition table shown in the gure illustrates how the Q output of each stage becomes the clock input to the next stage, while each ip- op is held in the toggle mode The output transitions assume that the clock, CLK, is a simple square wave (all JKs are negative edge triggered)

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The amino acid sequence of mouse dihydrofolate reductase. Numbers refer to sequential amino acids. The rst eighty- ve amino acids serve as the signal sequence for transport into mitochondria. Five -helical regions exist in the protein (A E). Positively and negatively charged amino acids are marked with ( ) and ( ) signs. (Reprinted by permission from E. C. Hurt and G. Schatz, A cytosolic

Q3 0 0 0 0 1 1 1

Q2 0 0 1 1 0 0 1 1

Q1 0 1 0 1 0 1 0 1

using linear, spherical, and angular bearings [24]

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This 3-bit ripple counter can easily be con gured as a divide-by-8 mechanism, simply by adding an AND gate To divide the input clock rate by 8, one output pulse should be generated for every eight clock pulses If one were to output a pulse every time a binary 111 combination occurs, a simple AND gate would suf ce to generate the required condition This solution is shown in Figure 1413 Note that the square wave is also included as an input to the AND gate; this ensures that the output is only as wide as the input signal This application of ripple counters is further illustrated in the following example

The McGraw Hill Companies, 2001

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Under aerobic conditions, yeast grows with a distinctive colony morphology. Under anaerobic conditions, the colonies are smaller, and the structures of the mitochondria are reduced. Occasionally, when growing aerobically, small, anaerobiclike colonies appear; but in these colonies, the mitochondria appear perfectly normal. These colonies are caused by petite mutations. When petites are crossed with the wild-type, three modes of inheritance emerge ( g. 17.6). The segregational petite, caused by mutation of a chromosomal gene, exhibits Mendelian inheritance. The neutral petite is lost immediately upon crossing to the wild-type. The suppressive petite shows variability in expression from one strain to the next but is able to convert the wild-type mitochondria to the petite form. All petites represent failures of mitochondrial function, whether the function is controlled by the mitochondria themselves or by the cell s nucleus; they usually lack one or another cytochrome. Although the mechanisms that produce neutral and suppressive petites are not known with certainty, their DNA has supplied some interesting information. In some petites, no change in the buoyant density of the DNA is found. (Buoyant density, a term that describes the position at which the DNA equilibrates during densitygradient centrifugation, is a measure of the composition of the molecule; see chapter 15.) In other petites, changes

Draw the timing diagram for the clock input, Q0 and Q1 , for the binary ripple counter of Figure 1414

Known Quantities: JK ip- op truth table (Figure 148) Find: Output of each ip- op, Q, as a function of the input clock transitions Assumptions: Assume negative-edge triggered devices Analysis: Following the timing diagram of Figure 1412, we see that Q0 switches at half the frequency of the clock input, and that Q1 switches at half the frequency of Q0 Hence the timing diagram shown below

in buoyant density range from very small to the complete absence of DNA Petites, therefore, can be the result of an approximation to a point mutation (with no measurable change in the buoyant density of the DNA), marked changes in the DNA, or the total absence of DNA In most petites, protein synthesis within the mitochondrion is lacking Any and all of these changes produce the petite (anaerobiclike) phenotype Neutral petites seem to have mitochondria that entirely lack DNA When neutral petites are crossed with the wild-type to form diploid cells, the normal mitochondria dominate During meiosis, virtually every spore receives large numbers of normal mitochondria; the progeny are, therefore, all normal Suppressive petites could exert their in uence over normal mitochondria in one of two ways The suppressive mitochondria might simply out-compete the normal mitochondria and take over; they might simply reproduce faster within a cell.

Fig 655: A load-pressure relationship based on a one-dimensional approximation [19]

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