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access read/write memory (RAM) is used to temporarily store data and instructions For example, the program that is executed by the CPU and the intermediate results of the calculations are stored in RAM Many microcontrollers also employ erasable programmable read-only memory (EPROM) or electrically erasable programmable read-only memory (EEPROM); these types of memory are used like ROM, but can be reprogrammed relatively easily using special EPROM burners EPROM and EEPROM can be very useful if one wishes to make small but important changes to the functions executed by the microcontroller For example, the microcontrollers used in automotive applications are usually the same from one model year to the next and across various vehicle platforms, but differences in control strategies and calibration data among vehicles, and changes and xes required from one model year to the next are usually accommodated by means of EPROMs Section 145 describes an automotive application Computer memory is arranged on the basis of bits, that is, a single digital variable with value of 0 or 1 Bits are grouped in bytes, consisting of 8 bits, and in words, consisting of 16 or 32 bits While the size of a word can vary, a byte always consists of 8 bits Small microcontrollers such as the 6805 have access to a relatively limited amount of memory (eg, 64 Kbytes); more powerful microcontrollers may access as much as 1 Mbyte Note that the memory capacity of a microcontroller is signi cantly smaller than that of the personal computers you are likely to use in your work Mass storage devices (magnetic and optical storage devices, such as hard drives and CD-ROMs) can also be used to increase a computer s access to data and information Access to such external devices is much slower than access to ROM and RAM, and is therefore usually not practical in embedded microcontrollers.

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Although sex linkage alters inheritance patterns, we do not expect different inheritance patterns, dependent on the parent of origin, from genes located on autosomal chromosomes. That is, the genotype of an offspring should be predicted by its alleles regardless of which parent donated which allele. That understanding has now been shown to be incorrect for a group of genes whose phenotypic effects are determined by the parent that donated a particular allele. This phenomenon is called imprinting (or molecular imprinting or parental imprinting). It falls under the general classi cation of an epigenetic effect, a term that has come to mean an effect due to an environmentally induced change in the genetic material but not causing a change in base pairs. It is a phenomenon of differential expression of the alleles at a locus depending on which parent the gene originated with. A striking example of imprinting in human beings involves two medical syndromes, both resulting in mental retardation. In Prader-Willi syndrome, affected persons are extremely obese; in Angelman syndrome, those affected are thin and sometimes referred to as happy puppets, because they exhibit a happy facial expression and erratic, jerky movements. It turns out that both syndromes are associated with deletions in the long arm of

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A computer program is a listing of instructions to be executed by the CPU The instructions are coded in a special machine language that consists of combinations of bytes To assist the programmer, each CPU instruction is associated to a mnemonic instruction code, which associated a short word or abbreviated code to each instruction (for example, the instruction ASL in the M68HC05 stands for arithmetic shift left) More sophisticated software development systems allow the instructor to program in a higher-level language (often the C programming language); the high-level language program is then translated into machine code by a compiler We shall devote one of the next subsections to programming issues Number Systems and Number Codes in Digital Computers

It should be already clear that computers operate on the basis of the binary number system The binary and hexadecimal number systems were introduced in 13 The hexadecimal system is particularly well suited for use in computer codes, because it allows a much more compact notation than the binary code would The hexadecimal code, as you will recall, permits expressing a four-bit binary number as a single-digit, using the numbers from 0 to 9 and the letters A

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chromosome 15, in bands 15q11 q13 The effect is seen in an individual arising from a gamete missing a 15q11 q13 region If the remaining region is of paternal origin, due to a deletion of the maternal gene, the offspring will have Angelman syndrome; if the remaining region is of maternal origin, the offspring will have PraderWilli syndrome This unusual situation indicates that the phenotype is dependent on the parent from which the region comes Recently, this region of chromosome 15 has come under intense scrutiny In males, from ve to seven genes are expressed from this area, and in females, one gene has been identi ed as the cause of Angelman syndrome, UBE3A (E3 ubiquitin protein ligase) It has been hypothesized that there is an imprinting center (IC), a region responsible for the control of imprinting.

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