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color) Flowers in heterozygotes (R1R2) have about half the red pigment of the owers in red homozygotes (R1R1) because the heterozygotes have only one copy of the allele that produces color, whereas the homozygotes have two copies As technology has improved, we have found more and more cases in which we can differentiate the heterozygote It is now clear that dominance and recessiveness are phenomena dependent on which alleles are interacting and on what phenotypic level we are studying For example, in Tay-Sachs disease, homozygous recessive children usually die before the age of three after suffering severe nervous system degeneration; heterozygotes seem to be normal As biologists have discovered how the disease works, they have made the detection of the heterozygotes possible As with many genetic diseases, the culprit is a defective enzyme (protein catalyst).

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Programming and Application Development in a Microcontroller Section 146 illustrates the use of a microcontroller in a very common application: the control of an automotive engine

Fig 730: A Moore aerostatic work spindle for ultra-precision machines [27]

This section gives the reader an insight to the functioning of a typical automotive engine controller The system described is based on the features of commercially available 32-bit microprocessors Table 147 lists the microcontroller s major characteristics

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Af icted homozygotes have no enzyme activity, heterozygotes have about half the normal level, and, of course, homozygous normal individuals have the full level In the case of Tay-Sachs disease, the defective enzyme is hexoseaminidase-A, needed for proper lipid metabolism Modern techniques allow technicians to assay the blood for this enzyme and to identify heterozygotes by their intermediate level of enzyme activity Two heterozygotes can now know that there is a 25% chance that any child they bear will have the disease They can make an educated decision as to whether or not to have children The other category in which the heterozygote is discernible occurs when the heterozygous phenotype is not on a scale somewhere between the two homozygotes, but actually expresses both phenotypes simultaneously We refer to this situation as codominance.

Table 147 Characteristics of automotive microcontroller I/O section inputs Variable reluctance sensor interfacea Hall sensor b interfaces (cam, crank) Analog input Exhaust gas oxygen sensors Discrete pull-ups to ignition Discrete pull-downs to ground PWM/frequency inputs Power and ground I/O section outputs Discrete low-side drivers PWM low-side drivers Low-side-driven fuel injectorsc Low-side-driven coil drivers High-side drivers High- and low-side current-controlled outputs Stepper motor driver H-bridge driver

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For example, people with blood type AB are heterozygotes who express both the A and B alleles for blood type (see the section entitled Multiple Alleles for more information about blood types) Electrophoresis (a technique described in chapter 5) lets us see proteins directly and also gives us many examples of codominance when we can see the protein products of both alleles..

Processor section Microcoded timing channels (TPU time processor unit) Discrete I/O channels PWM channels 8-bit ADC channels 10-bit ADC channels Boot memory ( ash) RAM Serial communication (RS-232, CAN, Class II, UART)

a See 16 Focus on Measurements: Magnetic Reluctance Position Sensor for an explanation of the operation of this sensor b See 7 Focus on Measurements: How Hall-Effect Current Transducers Work for an explanation of the operation of this sensor c See 11 for an example of a fuel injector driver

Fig 731: A Precitech Nanoform 200 work spindle [28] Fig 732: Front view of machine work [29]

Throughout the last century, botanists, zoologists, and microbiologists have adopted different methods for naming alleles. Botanists and mammalian geneticists tend to prefer the capital-lowercase scheme. Drosophila geneticists and microbiologists have adopted schemes that relate to the wild-type. The wild-type is the phenotype of the organism commonly found in nature. Though other naturally occurring phenotypes of the same species may also be present, there is usually an agreed-upon common

General Description The controller consists of a processor section and an input/output (I/O) section, mounted in an enclosure These two sections are usually combined onto one printed circuit board for cost considerations A generic controller may be programmed with different software for a wide range of production engine applications, or speci c hardware/software designs may be provided for each vehicle application Through embedded software, the controller is able to communicate with a personal computer (PC) for software debugging and development Serial bus based instrumentation is also available to assist in the development process, before an application is released for vehicle production A block diagram of a typical system con guration is given in Figure 1437

Power supply ADC (8-bit)

The McGraw Hill Companies, 2001

ADC (10-bit)

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