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DEFINITION 12.41 (HML: Hennessy-Milner logic). The following apply: Syntax: HML is the smallest set verifying: true HML, f, g HML = f g, g HML; f HML, a = a f HML. Semantics: The semantics of HML formulas is de ned with respect to an LTS LT S. As for modal logics, let us use s S and f HML : LT S, s |= f to indicate that formula f is satis ed in state s of the structure (here of the LTS) LT S. As usual, the semantics of a formula of HML is de ned by induction on the structure of the terms. In the following f and g HML and a . |=, the relation of satisfaction, is the smallest relation verifying: LT S, s |= true s S; LT S, s |= f g iff LT S, s |= f and LT S, s |= g; LT S, s |= f iff Not (LT S, s |= f ); LT S, s |= a f iff s S such that s s and LT S, s |= f. Abbreviations: f alse true, f g ( f g), [a]f a f f a1 a2 an f for = a1 a2 an .

When the impact of the side effects was better appreciated, the focus turned to nding corticoids that had a lower ratio of mineralocorticoid to glucocorticoid activity These programs produced a veritable host of corticoids The Thirteenth Edition of the Merck Index, for example, lists nonproprietary names for no fewer that 65 compounds in this class Although some of those agents did have somewhat reduced effects on minerals, none offered the long-sought true spilt between glucocorticoid and mineralocorticoid activity One of the rst modi cations of the cortisone molecule comprised introduction of an additional double bond in the A ring The product, prednisolone, is some four times more potent than cortisone (Fig 26) Increases in potency from modi cation of the structure at one position in the molecule are often additive to changes at some remote location.

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The additional double bond in ring A is consequently found in almost all of the later corticoids There is considerable lore in medicinal chemistry circles to the effect that replacement of hydrogen by a uorine atom in drugs often leads to a more potent derivative This expectation is borne out in the case of corticoids Replacement of hydrogen at the 9-position in prednisone by uorine leads to uorprednisolone acetate,59 a drug that shows yet another increase in potency Inclusion of an additional methyl group at the 6-position in the progesterone molecule led, as noted previously, to an increase in potency The analogs modi cation to prednisolone, leads to methylprednisolone,60 a drug about half again more potent than prednisone Addition of substituents at the 16-position has also provided several very potent corticoids Examples include dexamethasone,61 which has an additional methyl group at position 16.

The results of neuropsychological evaluation indicate that Naya currently is functioning within the average range of nonverbal intellectual ability as measured by the Perceptual Reasoning Index of the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV). Due to the signi cant verbal-performance discrepancy noted between the Verbal Comprehension and Perceptual Reasoning Index scores, and Naya s history of language delay and auditory processing disorder, it is felt that the Perceptual Reasoning Index score represents Naya s best estimate of intellectual potential (see Table 4.4). Additional assessment indicates that Naya demonstrated signi cant dif culty on the Tower subtest of Neuropsychological Assessment (NEPSY), which is a measure of sequential reasoning/problem-solving capability.

This compound is about 30 times more potent than cortisone Triamcinolone62 has a hydroxyl at that position.

claims, a practice common in the construction industry This situation is most likely to occur where the supply of goods or services exceeds demand, clients are price-conscious, and clients nd suppliers dif cult to differentiate Even with prior or post-bidding screening out of any contractors not deemed capable, reliable, and sound, the lowest bidder will have to be that member of the viable set of contractors who scores highest overall in the following categories: 1 Most optimistic in relation to cost uncertainties This may re ect expertise, but it may re ect a willingness to depart from implicit and explicit speci cation of the project, or ignorance of what is required 2 Most optimistic in relation to claims for additional revenue 3 Least concerned with considerations such as the impact on reputation or the chance of bankruptcy 4 Most desperate for work.

Example 2: 2 transformers and 2 generators (see Figure 1-28)

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